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Genetic scoring is a logical method of applying values for each gene in the efforts of predicting a given outcome based on conditions that make the genes react to stimulus or through the normal occurrence of gene activity in the body.
Genetic scoring may indicate markers as early as 18 years of age
Researchers from the Massachusetts General Hospital developed the genetic scoring method that will identify markers in people for risk of possible Alzheimer’s disease later on in life.
Dr. Elizabeth Mormino, one of the researchers, claims that the scoring method can tell whether a person may have Alzheimer’s disease later in life with young adults as early as 18 years old.
Published recently in the journal Neurology, Mormino said that this method may be able to help anticipate studies that could treat, or better yet, prevent the onset or Alzheimer’s disease early in life.
“Given that current clinical trials are testing whether therapies can slow memory and thinking decline among people at risk for the disease, it is critical to understand the influence of risk factors before symptoms are present,” says Mormino.
Alzheimer’s affects 5 million a year in the US
A degenerative disease in the brain, Alzheimer’s disease affects more than 5 million adults in the United States alone, with the number expected to triple in the next three decades.
The causes of Alzheimer’s is still unknown, however, numerous researches indicate that pathophysiologic processes of Alzheimer’s start to occur and my develop indicators that can be detected as early as 10 years before it may start to get full blown.
Mormino said that they strongly believe that genetics play a significant role in the development of diseases in the human body. A higher genetic score means a relative increased risk of Alzheimer’s.
This was based on results of a genome analysis involving 166 participants diagnosed with dementia and 1026 participants who did not have the problem, where among the symptoms were memory loss, decline in cognitive functions, the volume of matter in the hippocampus region and clinical progression of Alzheimer’s disease.
The results showed compelling evidence that the risks were higher for those with a higher genetic score.
“Overall, these analyses provide evidence that aggregate genetic risk of AD dementia exerts effects that are detectable before the clinical symptoms of dementia are present, even among young adults,” Mormino added.
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